A prospective, randomized, double-blinded comparison of thymoglobulin versus Atgam for induction immunosuppressive therapy: 10-year results.

Abstract

BACKGROUND:

Use of induction for renal transplantation is controversial because of the concerns about long-term safety and efficacy.

METHODS:

We compared the safety and efficacy at 10 years among patients randomized to thymoglobulin or Atgam induction in a single center, randomized, double-blinded trial. Quality-adjusted life years (QALYs) were calculated using utility weights.

RESULTS:

The primary composite endpoint of freedom from death, graft loss, or rejection, "event-free survival," was higher with thymoglobulin compared with Atgam (48% vs. 29%; P=0.011). At 10 years, patient survival (75% vs. 67%) and graft survival (48% vs. 50%) were similar, whereas acute rejection remained lower (11% vs. 42%, P=0.004) in the thymoglobulin group. The incidence of all types of cancer was numerically lower with thymoglobulin compared with Atgam (8% vs. 21%, P=NS). There were no posttransplant lymphoproliferative disorder in the thymoglobulin group and there were two cases in the Atgam group. There were no new cases of cytomegalovirus disease in either group. Mean serum creatinine levels were higher (1.7+/-0.5 mg/dL vs. 1.2+/-0.3 mg/dL; P=0.003) and estimated glomerular filtration rates tended to be lower (49+/-22 mL/min vs. 65+/-19 mL/min; P=0.065) in the thymoglobulin group. There were 0.53 QALYs gained (3.68 thymoglobulin vs. 3.15 Atgam; 16.7% improvement) from thymoglobulin compared with Atgam.

CONCLUSIONS:

This long-term follow-up showed that thymoglobulin was associated with higher event-free survival and improved QALYs, without increased posttransplant lymphoproliferative disorder or cytomegalovirus disease, compared with Atgam at 10 years.

• Authors: Karen L Hardinger, Sunny Rhee, Paula Buchanan, Matt Koch, Brent Miller, Decha Enkvetchakul, Rebecca Schuessler, Mark A Schnitzler, Daniel C Brennan
• Journal: Transplantation (Transplantation) Vol. 86 Issue 7 Pg. 947-52 (Oct 15 2008) ISSN: 1534-6080 [Electronic] United States
• PMID: 18852661 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Antilymphocyte Serum
• Immunosuppressive Agents
• thymoglobulin

Topics

• Adult
• Antibodies, Monoclonal (therapeutic use)
• Antilymphocyte Serum (therapeutic use)
• Disease-Free Survival
• Double-Blind Method
• Drug Therapy, Combination
• Female
• Follow-Up Studies
• Graft Rejection (epidemiology)
• Graft Survival (physiology)
• Humans
• Immunosuppression Therapy (methods)
• Immunosuppressive Agents (therapeutic use)
• Kidney Transplantation (immunology, mortality, physiology)
• Male
• Middle Aged
• Prospective Studies
• Quality of Life
• Safety