An open trial on short-term omeprazole therapy for gastric and duodenal ulcers.

Abstract

Omeprazole, a proton pump inhibitor, is a potent and long-acting gastric acid reducing agent. To assess its short-term efficacy and safety, 27 gastric ulcers (GU) and 40 duodenal ulcers (DU) in 64 patients were treated with 20 mg. Omeprazole was given once daily. At 2 weeks, the healing rate for gastric ulcers was 66% (18/27) and for duodenal ulcers, 78% (31/40). At 4 weeks, the healing rate was 85% and 95% for GU and DU, respectively. Pain relief was achieved after 2 weeks in 62% with GU and 61% in DU. There were no significant side effects noted during the treatment course. Omeprazole is effective and safe in the treatment of gastric and duodenal ulcers.

• Authors: J D Sollano, A C Espiritu, S Z Alvarez, J Y Perez
• Journal: Gastroenterologia Japonica (Gastroenterol Jpn) Vol. 26 Suppl 3 Pg. 271-4 (Jul 1991) ISSN: 0435-1339 [Print] Japan
• PMID: 1884955 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Omeprazole

Topics

• Adult
• Aged
• Aged, 80 and over
• Drug Evaluation
• Duodenal Ulcer (drug therapy)
• Duodenoscopy
• Female
• Gastroscopy
• Humans
• Male
• Middle Aged
• Omeprazole (therapeutic use)
• Stomach Ulcer (drug therapy)