Abstract | OBJECTIVE: METHODS: Serum leptin, resistin, visfatin, retinol-binding protein-4, adiponectin, glucose, insulin, and inflammatory parameters were analyzed in 93 patients with inactive IBD (49 with Crohn's disease [CD], 44 with ulcerative colitis [UC]), 35 patients with active IBD (18 with CD, 17 with UC), and 37 age- and body mass index-matched healthy controls. Ninety-two patients were followed for 6 mo. RESULTS:
Leptin was similar in patients with IBD and controls, whereas resistin and visfatin were increased in patients with active disease but not in those in remission. In active and inactive disease, adiponectin was decreased (P < 0.001) and retinol-binding protein-4 was increased (P < 0.001) compared with controls. About 60% of patients with IBD showed increased levels of insulin, whereas serum glucose remained normal, resulting in increased homeostasis model assessment values in most patients. Hyperinsulinemia was associated with the decrease in adiponectin (r = -0.572, P < 0.001) and proved to be an independent protective factor for 6-mo maintenance of remission (P = 0.016). CONCLUSION: IBD led to largely similar alterations in circulating adipokines and hyperinsulinemia in patients with CD and those with UC. The unexpected protective effect of hyperinsulinemia on relapse rate denotes the role of the metabolic-inflammatory response as a modulator in IBD.
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Authors | Luzia Valentini, Eva Katrin Wirth, Ulrich Schweizer, Susanne Hengstermann, Lennart Schaper, Thomas Koernicke, Ekkehart Dietz, Kristina Norman, Carsten Buning, Brigitte M Winklhofer-Roob, Herbert Lochs, Johann Ockenga |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
Vol. 25
Issue 2
Pg. 172-81
(Feb 2009)
ISSN: 0899-9007 [Print] United States |
PMID | 18849144
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adiponectin
- Inflammation Mediators
- Leptin
- Resistin
- Retinol-Binding Proteins
- Nicotinamide Phosphoribosyltransferase
|
Topics |
- Adiponectin
(blood)
- Adolescent
- Adult
- Aged
- Case-Control Studies
- Colitis, Ulcerative
(blood, complications)
- Crohn Disease
(blood, complications)
- Female
- Humans
- Hyperinsulinism
(etiology, prevention & control)
- Inflammation Mediators
(blood)
- Leptin
(blood)
- Male
- Middle Aged
- Nicotinamide Phosphoribosyltransferase
(blood)
- Resistin
(blood)
- Retinol-Binding Proteins
(metabolism)
- Young Adult
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