Abstract | OBJECTIVE: METHODS: Seventy-nine patients were evaluated. Disease activity was evaluated by a pediatric rheumatologist. Anthropometric data were classified according to the World Health Organization standards. Tanner growth velocity curves were used; values below the Z-score < or = -2 were considered low growth velocity. Serum concentrations of interleukin 6 (IL-6) were measured by ELISA, and values > 1 pg/ml were considered elevated. RESULTS: The prevalence of low growth velocity was 25.3%, and it was associated with active disease on followup visit, elevated IL-6, erythrocyte sedimentation rate and C-reactive protein, and higher cumulative glucocorticoid doses. In the multiple linear regression with growth velocity as the dependent variable, only elevated IL-6 level was independently and negatively associated with growth velocity. CONCLUSION: Low growth velocity is highly prevalent in children with JIA. Elevated IL-6 levels seem to have an important negative influence on growth in these children, while total glucocorticoid exposure appears to be a secondary factor.
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Authors | Leticia S Souza, Sandra H Machado, Claiton V Brenol, Joao Carlos T Brenol, Ricardo M Xavier |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 35
Issue 11
Pg. 2265-71
(Nov 2008)
ISSN: 0315-162X [Print] Canada |
PMID | 18843772
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Glucocorticoids
- IL6 protein, human
- Interleukin-6
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Topics |
- Adolescent
- Anthropometry
- Arthritis, Juvenile
(drug therapy, epidemiology, immunology)
- Biomarkers
(blood)
- Child
- Female
- Glucocorticoids
(therapeutic use)
- Growth Disorders
(epidemiology, immunology)
- Humans
- Interleukin-6
(blood)
- Linear Models
- Male
- Prevalence
- Puberty
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