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Growth velocity and interleukin 6 concentrations in juvenile idiopathic arthritis.

AbstractOBJECTIVE:
.To evaluate associations of growth velocity with inflammatory markers and cumulative dose of glucocorticoid in a cohort of patients with juvenile idiopathic arthritis (JIA) followed during 1 year.
METHODS:
Seventy-nine patients were evaluated. Disease activity was evaluated by a pediatric rheumatologist. Anthropometric data were classified according to the World Health Organization standards. Tanner growth velocity curves were used; values below the Z-score < or = -2 were considered low growth velocity. Serum concentrations of interleukin 6 (IL-6) were measured by ELISA, and values > 1 pg/ml were considered elevated.
RESULTS:
The prevalence of low growth velocity was 25.3%, and it was associated with active disease on followup visit, elevated IL-6, erythrocyte sedimentation rate and C-reactive protein, and higher cumulative glucocorticoid doses. In the multiple linear regression with growth velocity as the dependent variable, only elevated IL-6 level was independently and negatively associated with growth velocity.
CONCLUSION:
Low growth velocity is highly prevalent in children with JIA. Elevated IL-6 levels seem to have an important negative influence on growth in these children, while total glucocorticoid exposure appears to be a secondary factor.
AuthorsLeticia S Souza, Sandra H Machado, Claiton V Brenol, Joao Carlos T Brenol, Ricardo M Xavier
JournalThe Journal of rheumatology (J Rheumatol) Vol. 35 Issue 11 Pg. 2265-71 (Nov 2008) ISSN: 0315-162X [Print] Canada
PMID18843772 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers
  • Glucocorticoids
  • IL6 protein, human
  • Interleukin-6
Topics
  • Adolescent
  • Anthropometry
  • Arthritis, Juvenile (drug therapy, epidemiology, immunology)
  • Biomarkers (blood)
  • Child
  • Female
  • Glucocorticoids (therapeutic use)
  • Growth Disorders (epidemiology, immunology)
  • Humans
  • Interleukin-6 (blood)
  • Linear Models
  • Male
  • Prevalence
  • Puberty

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