Abstract | BACKGROUND: METHODS: In a randomized, prospective, clinical multicenter trial, 92 subjects with severe chronic periodontitis were treated with scaling and root planing (SRP) alone (control group; n = 21), SRP plus adjunctive doxycycline (DOX group; n = 36), or SRP plus adjunctive MOX (MOX group; n = 35). Probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were recorded at baseline and at 3, 6, and 12 months after non-surgical periodontal treatment. The load of periodontopathogens, the level of interleukin-8, and the activities of granulocyte elastase and myeloperoxidase were also measured. RESULTS: All three procedures led to significant reductions in PD, CAL, and BOP. PD reduction was significantly greater (P <0.05) in the MOX group (2.46 +/- 1.17 mm at 6 months and 2.84 +/- 1.53 mm at 12 months) compared to the DOX group (1.85 +/- 1.24 mm and 2.19 +/- 1.13 mm at 6 and 12 months, respectively) and the controls (1.77 +/- 0.57 mm and 1.86 +/- 0.56 mm at 6 and 12 months, respectively). Only in the MOX group was the load of all investigated bacteria and all inflammatory parameters reduced at each appointment compared to baseline. CONCLUSIONS:
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Authors | Arndt Guentsch, Holger Jentsch, Wolfgang Pfister, Thomas Hoffmann, Sigrun Eick |
Journal | Journal of periodontology
(J Periodontol)
Vol. 79
Issue 10
Pg. 1894-903
(Oct 2008)
ISSN: 0022-3492 [Print] United States |
PMID | 18834244
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Infective Agents
- Aza Compounds
- Fluoroquinolones
- Interleukin-8
- Quinolines
- Peroxidase
- Leukocyte Elastase
- Doxycycline
- Moxifloxacin
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Topics |
- Adult
- Aggregatibacter actinomycetemcomitans
(isolation & purification)
- Anti-Bacterial Agents
(therapeutic use)
- Anti-Infective Agents
(therapeutic use)
- Aza Compounds
(therapeutic use)
- Bacteroides
(isolation & purification)
- Chronic Periodontitis
(drug therapy, microbiology, therapy)
- Colony Count, Microbial
- Combined Modality Therapy
- Dental Scaling
- Doxycycline
(therapeutic use)
- Female
- Fluoroquinolones
- Follow-Up Studies
- Gingival Hemorrhage
(drug therapy, therapy)
- Humans
- Interleukin-8
(analysis)
- Leukocyte Elastase
(analysis)
- Male
- Moxifloxacin
- Periodontal Attachment Loss
(drug therapy, therapy)
- Periodontal Pocket
(drug therapy, therapy)
- Peroxidase
(analysis)
- Porphyromonas gingivalis
(isolation & purification)
- Prospective Studies
- Quinolines
(therapeutic use)
- Root Planing
- Treatment Outcome
- Treponema denticola
(isolation & purification)
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