[The efficacy of alteplase in pulmonary embolism treatment].

Abstract

The results of pulmonary embolism treatment with streptase in 76 patients are discussed. All patients had submassive or massive pulmonary embolism. 66 (86%) of patients recovered. Thrombolysis with the use of heparin was performed in 9 patients, death occurred in 5 of them. Of 20 patients treated with "Actilize", death was reported in three cases. Authors consider alteplase to be highly effective in the treatment of massive pulmonary embolism. In case of late diagnostics of pulmonary embolism, especially recurrent, thrombolytic therapy remains to be effective up to 2 weeks after primary embolization.

• Authors: N N Malinovskiĭ, A K Gruzdev, L M Beskaeva, D V Sal' nikov, K Iu Nikerov, A S Abramov, I N Fineshin
• Journal: Khirurgiia (Khirurgiia (Mosk)) Issue 7 Pg. 4-7 ( 2008) ISSN: 0023-1207 [Print] Russia (Federation)
• PMID: 18833155 (Publication Type: Comparative Study, Evaluation Study, Journal Article)

Chemical References

• Fibrinolytic Agents
• Platelet Aggregation Inhibitors
• Heparin
• Streptokinase
• Tissue Plasminogen Activator
• Aspirin

Topics

• Adult
• Aged
• Aged, 80 and over
• Angiography
• Aspirin (administration & dosage, therapeutic use)
• Female
• Fibrinolytic Agents (administration & dosage, therapeutic use)
• Heparin (administration & dosage, therapeutic use)
• Humans
• Male
• Middle Aged
• Platelet Aggregation Inhibitors (administration & dosage, therapeutic use)
• Pulmonary Embolism (diagnosis, diagnostic imaging, drug therapy, mortality)
• Streptokinase (administration & dosage, therapeutic use)
• Time Factors
• Tissue Plasminogen Activator (administration & dosage, therapeutic use)
• Treatment Outcome