[Malignant hyperthermia: halothane kinetics in a study model of muscular contraction. Head space determination and comparison with a mathematical model].

Abstract

Testing in vitro are used to locate malignant hyperthemia susceptible subjects. They use muscular contraction in response to anesthetic administration, particularly Halothane. They allow to classify subjects in three classes: susceptible, non susceptible and intermediate. Halothane was dosed by chromatography in the three compartments of a bath for isolated organs with a muscular fiber during steady concentrations were given and after wash out. Partition coefficient were determinated and compared to a calculated model. They are variable with physical conditions of the circuit. This results confirmed published data and give some possibilities to improve such tests to ascertain the subjects susceptibility to Halothane.

• Authors: D Theunynck, M Imbenotte, E Guevart, J M Haguenoer
• Journal: Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression (Agressologie) Vol. 32 Issue 2 Pg. 121-5 ( 1991) ISSN: 0002-1148 [Print] France
• Vernacular Title: Hyperthermie maligne: cinétique de l'halothane dans un modèle d'étude de la contraction musculaire. Dosage par Head Space et comparaison avec une modélisation par le calcul.
• PMID: 1883034 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Halothane

Topics

• Chromatography
• Disease Susceptibility
• Halothane (administration & dosage, pharmacokinetics)
• Humans
• In Vitro Techniques
• Malignant Hyperthermia (physiopathology)
• Models, Molecular
• Models, Theoretical
• Muscles (metabolism)
• Nebulizers and Vaporizers