Reversible conductive hearing loss: restored activity in the central auditory system.

Abstract

The effect of a reversible, unilateral hearing loss on 2-deoxyglucose (2-DG) uptake in the central auditory system was studied using young gerbils. All animals had a unilateral conductive hearing loss (CHL), induced by atresia, on postnatal day 21 (P21). One week later, on P28, animals had their atresia repaired (CHL/R), or not repaired (CHL/NR), and CHL/NR animals entered the 2-DG experiments. CHL/R animals were allowed a 1-week period of restored binaural hearing experience prior to entering 2-DG experiments on P35. Animals in each group were injected with 2-DG and exposed to ambient sounds for 45 min prior to sacrifice. Uptake of 2-DG was measured in the anteroventral cochlear nucleus (AVCN), the medial superior olive (MSO), and the inferior colliculus (IC) on both sides of the brain. In CHL/NR animals, there were significant differences in uptake between the AVCN, MSO, and IC ipsilateral versus contralateral to the manipulated ear, indicating an imbalance in ascending afferent activity. In CHL/R animals, there were no significant differences, suggesting that 1 week after CHL repair, the appearance of balanced afferent activity had been restored.

• Authors: K A Hutson, D Durham, D L Tucci
• Journal: Audiology & neuro-otology (Audiol Neurootol) Vol. 14 Issue 2 Pg. 69-77 ( 2009) ISSN: 1421-9700 [Electronic] Switzerland
• PMID: 18827477 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: 2008 S. Karger AG, Basel.

Chemical References

• Deoxyglucose

Topics

• Animals
• Cochlear Nucleus (metabolism, physiopathology)
• Deoxyglucose (pharmacokinetics)
• Disease Models, Animal
• Gerbillinae
• Hearing Loss, Conductive (metabolism, physiopathology)
• Hearing Loss, Unilateral (metabolism, physiopathology)
• Inferior Colliculi (metabolism, physiopathology)
• Olivary Nucleus (metabolism, physiopathology)
• Recovery of Function (physiology)