[An emulsion of fluorocarbons as a protective agent against myocardial ischemia].

Abstract

Acute myocardial ischemia was induced by reducing the lumen of the anterior descending branch of the left coronary artery in 32 mongrel dogs. Following 60 min of ischemia, 16 animals were infused perfluorine carbon emulsion (10 ml/kg) and 16 were given saline. Alteration in hemodynamics, myocardial contractility, coronary blood flow, as well as pH and pO2 in the ischemic area were examined. The analysis of the results showed that carbon tetrafluoride emulsion, in contrast to saline, substantially increased coronary blood flow and oxygen supply in the ischemic area decreased myocardial ischemic and reperfusion lesion, improved hemodynamic parameters and myocardial contractility.

• Authors: B I Islamov, Iu V Ladilov, V A Buevich, R V Bobrovskiĭ
• Journal: Vestnik Akademii meditsinskikh nauk SSSR (Vestn Akad Med Nauk SSSR) Issue 3 Pg. 39-43 ( 1991) ISSN: 0002-3027 [Print] Russia (Federation)
• Vernacular Title: Emul'siia ftoruglerodov kak sredstvo protivoishemicheskoĭ zashchity miokarda.
• PMID: 1882539 (Publication Type: English Abstract, Journal Article)

Chemical References

• Emulsions
• Fluorocarbons
• perftoran

Topics

• Animals
• Coronary Circulation (drug effects)
• Coronary Disease (drug therapy)
• Dogs
• Emulsions
• Fluorocarbons (administration & dosage, therapeutic use)
• Myocardial Reperfusion Injury (prevention & control)
• Stimulation, Chemical