Antibacterial effects of three experimental quaternary ammonium salt (QAS) monomers on bacteria associated with oral infections.

Abstract

The aim of this study was to test the antibacterial effects of three experimental quaternary ammonium salt monomers in order to evaluate their potential applications as dental materials. In vitro susceptibility testing of the monomers was performed by the broth dilution method on bacteria associated with oral infections: Streptococcus mutans ATCC 25175, Actinomyces viscosus ATCC 15987, Staphylococcus aureus ATCC 29213 and Lactobacillus casei ATCC 393. The time-kill kinetics of the monomer with relatively higher antibacterial activity against S. mutans were also investigated. It was found that all the tested bacteria strains were susceptible to the three monomers, among which methacryloxylethyl cetyl ammonium chloride (DMAE-CB) exhibited the lowest minimal inhibitory concentrations, ranging from 1.2 to 4.8 microg/ml. The time-kill curve showed that DMAE-CB achieved 99.44% killing at 19.2 microg/ml (4 times the minimal bactericidal concentration) against S. mutans after 1 min and 100% killing within 10 min of contact. This result indicates that the quaternary ammonium salt monomer DMAE-CB may be a candidate antibacterial agent for incorporation into dental restorative materials.

• Authors: Yu-Hong Xiao, Ji-Hua Chen, Ming Fang, Xiao-Dong Xing, Hui Wang, Ying-Jie Wang, Fang Li
• Journal: Journal of oral science (J Oral Sci) Vol. 50 Issue 3 Pg. 323-7 (Sep 2008) ISSN: 1343-4934 [Print] Japan
• PMID: 18818469 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Quaternary Ammonium Compounds

Topics

• Anti-Bacterial Agents (chemistry, pharmacology)
• Bacteria, Anaerobic (drug effects)
• Colony Count, Microbial
• Microbial Sensitivity Tests
• Molecular Structure
• Mouth Diseases (microbiology)
• Quaternary Ammonium Compounds (chemistry, pharmacology)
• Staphylococcus aureus (drug effects)