Plasma morphine and morphine-6-glucuronide patterns in cancer patients after oral, subcutaneous, sublabial and rectal short-term administration.

Abstract

Clinical studies on the effectiveness of morphine administered through different routes are contradictory. In order to further elucidate this point, the plasma concentrations of morphine and its 3- and 6-glucuronated metabolites were measured after short-term oral, sublabial, rectal and subcutaneous administration of the opiate. The bioavailability of free morphine and the 6-glucuronated active metabolite was comparable through the different routes. It was concluded that the choice of the route of morphine administration should be mainly guided by the needs of each individual patient.

• Authors: M Breda, M Bianchi, C Ripamonti, E Zecca, V Ventafridda, A E Panerai
• Journal: International journal of clinical pharmacology research (Int J Clin Pharmacol Res) Vol. 11 Issue 2 Pg. 93-7 ( 1991) ISSN: 0251-1649 [Print] Switzerland
• PMID: 1879993 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Morphine Derivatives
• morphine-6-glucuronide
• Morphine

Topics

• Aged
• Drug Administration Routes
• Female
• Humans
• Male
• Middle Aged
• Morphine (administration & dosage, blood, therapeutic use)
• Morphine Derivatives (blood)
• Neoplasms (physiopathology)
• Pain (drug therapy)