[A case of advanced gastric cancer with pulmonary carcinomatous lymphangitis and paraaortic lymph node metastases responding to combination chemotherapy of S-1 and irinotecan(CPT-11)].

Abstract

A 70-year-old woman with pulmonary carcinomatous lymphangitis and paraaortic lymph node metastases due to gastric cancer, was treated by combination chemotherapy of S-1 and irinotecan (CPT-11). After one course of the chemotherapy, pulmonary carcinomatous lymphangitis and paraaortic lymph node metastases were remarkably improved. Diet intake was improving and cancer pain remarkably declined. Because the origin of gastric cancer was not improved, total gastrectomy, distal pancreatectomy and splenectomy were performed. After surgery, relapse of pulmonary carcinomatous lymphangitis caused death of the patient. The combination chemotherapy of S-1 and CPT-11 was effective for pulmonary carcinomatous lymphangitis and paraaortic lymph nodes metastases due to gastric cancer. However, careful consideration is required since surgery is performed on a patient who had suffered pulmonary carcinomatous lymphangitis.

• Authors: Hiroshi Ohtani, Yuichi Arimoto, Kohei Nishio, Kenji Adachi, Hiroko Ohba, Machiko Shintani, Saburo Yui
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 35 Issue 9 Pg. 1563-7 (Sep 2008) ISSN: 0385-0684 [Print] Japan
• PMID: 18799912 (Publication Type: Case Reports, Journal Article)

Chemical References

• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Irinotecan
• Camptothecin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Aorta (drug effects)
• Camptothecin (analogs & derivatives, therapeutic use)
• Drug Combinations
• Female
• Gastroscopy
• Humans
• Irinotecan
• Lung Neoplasms (diagnostic imaging, drug therapy, secondary)
• Lymphangitis (diagnostic imaging, drug therapy, etiology)
• Lymphatic Metastasis (diagnostic imaging)
• Neoplasm Staging
• Oxonic Acid (therapeutic use)
• Stomach Neoplasms (complications, diagnostic imaging, drug therapy, pathology)
• Tegafur (therapeutic use)
• Tomography, X-Ray Computed
• Treatment Failure