Mediastinal seminoma in a patient with multiple endocrine neoplasia type 1.

Abstract

A patient with multiple endocrine neoplasia type 1 (MEN1) developed a mediastinal seminoma. The patient was a 46-year-old man who presented with respiratory symptoms. A diagnosis of mediastinal seminoma was pathologically confirmed and a complete remission was achieved by chemotherapy. During his hospital stay, hyperparathyroidism and multiple pancreatic tumors associated with hypergastrinemia were found. A diagnosis of MEN1 was made genetically. Although patients with MEN1 manifest a variety of neoplastic disorders, no cases of concurrent seminoma and MEN1 have previously been reported. In addition, no etiological relationship between seminoma and MEN1 has yet been reported.

• Authors: Tsuyoshi Tanabe, Masanori Yasuo, Kenji Tsushima, Kazuhisa Urushihata, Hiroshi Yamamoto, Masayuki Hanaoka, Tomonobu Koizumi, Keisaku Fujimoto, Yoshitaka Yamazaki, Yoshiki Hirose, Hideaki Hamano, Akihiro Sakurai, Keishi Kubo
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 47 Issue 18 Pg. 1615-9 ( 2008) ISSN: 1349-7235 [Electronic] Japan
• PMID: 18797122 (Publication Type: Case Reports, Journal Article)

Topics

• Humans
• Male
• Mediastinal Neoplasms (diagnosis, drug therapy, pathology)
• Middle Aged
• Multiple Endocrine Neoplasia Type 1 (diagnosis)
• Neoplasms, Multiple Primary (diagnosis, drug therapy)
• Remission Induction
• Seminoma (diagnosis, drug therapy, pathology)