Lack of association of delta-aminolevulinic acid dehydratase genotype with blood lead levels in environmentally exposed children of Uygur and Han populations.
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| Abstract | AIM: A cross-section study was conducted to explore the association between polymorphism of delta-aminolevulinic acid dehydratase (ALAD) and lead poisoning in Uygur and Han children in China. METHODS: The ALAD genotyping was determined by PCR-RFLP in 443 Uygur and 469 Han children aged 6-10 years from Urumqi in Xinjiang province. RESULTS: The blood lead levels of 912 environmentally exposed children ranged from 0.5 to 48.2 microg/dL, with a mean of 5.45 microg/dL and a standard deviation of 0.22 microg/dL, and 23. Thirty-one percent individuals were with blood lead level > or =10 microg/dL. The mean and standard deviation of blood lead levels were 5.57 +/- 0.223 microg/dL and 5.30 +/- 0.224 microg/dL in Uygur and Han children, respectively. The frequencies of the allele ALAD1 and ALAD2 in Uygur subjects were 90.52% and 9.48%, and in Han subjects were 95.73% and 4.27%, respectively (chi-square = 19.55, p < 0.05). No statistic correlation between the distribution of ALAD alleles and the blood lead level was found in both populations. CONCLUSION: A significant difference was seen in the frequency distribution of ALAD genotype between the different races. The genetic susceptibility of ALAD polymorphism to lead toxicity may exhibit in a lead dose-dependent manner.
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| Authors | Yan Chen, Jiang-Xia Zhao, Ji-Wen Liu, Jun Cui, Ling Li, Wei Tian |
| Journal | Acta paediatrica (Oslo, Norway : 1992) (Acta Paediatr) Vol. 97 Issue 12 Pg. 1717-20 (Dec 2008) ISSN: 1651-2227 [Electronic] Norway |
| PMID | 18795909 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't) |
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