Abstract | BACKGROUND & AIMS: METHODS: We created a transgenic mouse model (elastase sshIL-1beta) in which the rat elastase promoter drives the expression of human interleukin-1beta. Mice were followed up for up to 2 years. Pancreata of elastase sshIL-1beta mice were analyzed for chronic pancreatitis-associated histologic and molecular changes. To study the potential effect of p53 mutation in chronic pancreatitis, elastase sshIL-1beta mice were crossed with p53(R172H) mice. RESULTS: CONCLUSIONS:
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Authors | Frederic Marrache, Shui Ping Tu, Govind Bhagat, Swaroop Pendyala, Christoph H Osterreicher, Shanisha Gordon, Vigneshwaran Ramanathan, Melitta Penz-Osterreicher, Kelly S Betz, Zhigang Song, Timothy C Wang |
Journal | Gastroenterology
(Gastroenterology)
Vol. 135
Issue 4
Pg. 1277-87
(Oct 2008)
ISSN: 1528-0012 [Electronic] United States |
PMID | 18789941
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interleukin-1beta
- Pancreatic Elastase
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Topics |
- Animals
- Disease Models, Animal
- Female
- Fibrosis
- Gene Expression
(physiology)
- Humans
- Interleukin-1beta
(genetics)
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Transgenic
- Pancreas
(pathology, physiopathology)
- Pancreatic Elastase
(genetics)
- Pancreatitis, Chronic
(genetics, pathology, physiopathology)
- Phenotype
- Promoter Regions, Genetic
(genetics)
- Rats
- Severity of Illness Index
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