Abstract | CONTEXT: OBJECTIVE: To investigate the immunohistochemical staining profile in 4 primary clear cell carcinomas of the urinary tract, including P504S, which has not been previously evaluated in these tumors. DESIGN: Four cases of clear cell adenocarcinoma were retrieved from our archives: 2 cases from the urinary bladder (one each from a man and a woman) and 2 cases from the urethra (both from women, 1 in a diverticulum). Immunohistochemistry performed on the cases were P504S, K903, cytokeratin (CK) 7, CK20, CA 125, and p63. RESULTS: We found that clear cell carcinomas had a distinct immunoreactive profile: strongly positive for P504S, K903, and CK7, and negative for p63. Two cases were also positive for CA 125 and CK20. CONCLUSION: The immunohistochemical profile of clear cell carcinomas shares some similarity to conventional urothelial carcinoma; however, it deviates from those tumors in being positive for P504S and negative for p63. This staining profile may suggest a nonurothelial origin for these tumors, may serve as a useful tool in the differential diagnosis of this tumor, and may reflect its etiology. Because similar expression of P504S is also seen in nephrogenic adenomas, this marker should not be used to differentiate nephrogenic adenomas from clear cell adenocarcinomas.
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Authors | Katherine Sun, Youming Huan, Pamela D Unger |
Journal | Archives of pathology & laboratory medicine
(Arch Pathol Lab Med)
Vol. 132
Issue 9
Pg. 1417-22
(Sep 2008)
ISSN: 1543-2165 [Electronic] United States |
PMID | 18788852
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- CA-125 Antigen
- CKAP4 protein, human
- Keratin-20
- Keratin-7
- Membrane Proteins
- Racemases and Epimerases
- alpha-methylacyl-CoA racemase
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Topics |
- Adenocarcinoma, Clear Cell
(metabolism, pathology)
- Aged
- Biomarkers, Tumor
(analysis)
- CA-125 Antigen
(biosynthesis)
- Female
- Humans
- Immunohistochemistry
- Keratin-20
(biosynthesis)
- Keratin-7
(biosynthesis)
- Male
- Membrane Proteins
(biosynthesis)
- Middle Aged
- Racemases and Epimerases
(biosynthesis)
- Urethral Neoplasms
(metabolism, pathology)
- Urinary Bladder Neoplasms
(metabolism, pathology)
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