Abstract | HISTORY: A 48-year-old patient with Crohn's disease was admitted to our hospital with fatigue, icterus, hepatosplenomegaly and ascites. INVESTIGARTIOS: The whole blood count revealed a pancytopenia, hyperbilirubinemia and slightly elevated transaminases. Examination of the liver histology showed areas of enlarged hyperplastic hepatocytes adjacent to areas of atrophic hepatocytes and dilated sinusoids. DIAGNOSIS, TREATMENT AND COURSE: CONCLUSIONS: NRH is a rare but potentially serious complication of azathioprine therapy. Other causes include various rheumatological, vascular and myeloproliferative diseases. When azathioprine is prescribed it must be borne in mind that it can cause NRH as a potential adverse effect, and liver enzymes should be measured at regular follow-up examinations.
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Authors | M Schumann, J C Preiss, C Loddenkemper, U Günther, R Somasundaram, B Siegmund, M Zeitz |
Journal | Deutsche medizinische Wochenschrift (1946)
(Dtsch Med Wochenschr)
Vol. 133
Issue 38
Pg. 1897-900
(Sep 2008)
ISSN: 1439-4413 [Electronic] Germany |
Vernacular Title | Noduläre regenerative Hyperplasie als Nebenwirkung von Azathioprin bei Morbus Crohn. |
PMID | 18788068
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Immunosuppressive Agents
- Azathioprine
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Topics |
- Ascites
(etiology)
- Azathioprine
(adverse effects, therapeutic use)
- Blood Cell Count
- Crohn Disease
(drug therapy)
- Diagnosis, Differential
- Fatigue
(etiology)
- Focal Nodular Hyperplasia
(chemically induced, complications, pathology)
- Humans
- Immunosuppressive Agents
(adverse effects, therapeutic use)
- Jaundice
(etiology)
- Liver
(enzymology, pathology)
- Male
- Middle Aged
- Pancytopenia
(chemically induced)
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