Abstract |
Recent studies have demonstrated that melanocortin-1 receptor (MC1R) variants increase the risk of melanomas harboring BRAF mutations. This finding provides insight into the relationship between host genotype and selection for somatic mutation type. Additional larger studies are required in diverse populations to further examine the interaction between MC1R and BRAF in different melanoma subtypes.
|
Authors | Elke Hacker, Nicholas K Hayward |
Journal | The Journal of investigative dermatology
(J Invest Dermatol)
Vol. 128
Issue 10
Pg. 2354-6
(Oct 2008)
ISSN: 1523-1747 [Electronic] United States |
PMID | 18787543
(Publication Type: Comment, Editorial)
|
Chemical References |
- Receptor, Melanocortin, Type 1
- BRAF protein, human
- Proto-Oncogene Proteins B-raf
|
Topics |
- Genetic Predisposition to Disease
- Genetic Variation
- Germ-Line Mutation
- Humans
- Melanoma
(genetics)
- Mutation
- Proto-Oncogene Proteins B-raf
(genetics)
- Receptor, Melanocortin, Type 1
(genetics)
- Skin Neoplasms
(genetics)
|