Abstract | OBJECTIVE: DESIGN: We investigated the incidence of pituitary tumors in the Seveso population exposed to 2,3,7,8-tetrachlorodibenzo-para-dioxin following an industrial accident in 1976. METHODS: Through the hospital discharge registration system of Lombardy Region, we identified incident cases of pituitary adenomas between 1976 and 1996 in the Seveso population, subdivided in zone A (n=804), B (n=5.941), and R (n=38.624) according to high, intermediate, and low exposure to dioxin respectively, and in the surrounding non-contaminated area, as reference (n=232 745). RESULTS: CONCLUSIONS: The study is unique with regard to the availability of epidemiological and clinical data in an area of relatively pure dioxin exposure. The study indicates no statistically significant increase of incident pituitary tumors in this area, although the tendency toward a higher risk (three cases in zones A and B) of pituitary tumors in subjects exposed to high-intermediate dioxin concentrations in comparison with nonexposed population suggests the need for extended follow-up.
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Authors | Angela Cecilia Pesatori, Andrea Baccarelli, Dario Consonni, Andrea Lania, Paolo Beck-Peccoz, Pier Alberto Bertazzi, Anna Spada |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 159
Issue 6
Pg. 699-703
(Dec 2008)
ISSN: 1479-683X [Electronic] England |
PMID | 18787049
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dioxins
- Intracellular Signaling Peptides and Proteins
- Soil Pollutants
- aryl hydrocarbon receptor-interacting protein
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Topics |
- Accidents, Occupational
- Adenoma
(chemically induced, epidemiology, genetics)
- Adolescent
- Adult
- Aged
- Dioxins
(poisoning)
- Environmental Exposure
(adverse effects)
- Humans
- Intracellular Signaling Peptides and Proteins
(genetics)
- Italy
(epidemiology)
- Middle Aged
- Pituitary Neoplasms
(chemically induced, epidemiology, genetics)
- Population Surveillance
(methods)
- Soil Pollutants
(poisoning)
- Young Adult
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