The prevalence of hepatitis B co-infection in a South African urban government HIV clinic.

Abstract

OBJECTIVE:

There are an estimated 350 million hepatitis B carriers worldwide. In South Africa the prevalence of mono-infection with hepatitis B has been estimated to range from 1% in urban areas to approximately 10% in rural areas. The exact prevalence of hepatitis B in the HIV-infected population has not been well established. Hepatitis B screening is not standard practice in government HIV clinics. Co-infection with hepatitis B and HIV can influence antiretroviral treatment and prognosis of both diseases. The purpose of this study was to evaluate the prevalence of hepatitis B/HIV coinfection.

DESIGN:

This is believed to be the first prospective observational report on the prevalence of hepatitis B/HIV co-infection in South Africa. Patients on whom hepatitis B serological tests could not have been done previously were recruited from an HIV clinic in a regional hospital in Johannesburg. Standard hepatitis B serological tests were performed.

RESULTS:

Five hundred and two participants were screened. The cohort's average age was 37 +/- 9 years and the average CD4 count was 128 cells/pi. Twenty-four (4.80%) were hepatitis B surface antigen positive. Nearly half (47%) of the participants showed some evidence of hepatitis B exposure. The risk of hepatitis B co-infection was not significantly different when analysed in terms of sex, race, CD4 count or age. Liver function tests were not a good predictor of hepatitis B infection.

CONCLUSION:

The rate of hepatitis B infection, as defined by hepatitis B surface antigen positivity in HIV-infected individuals in urban South Africa was 5 times the rate in people who were not HIV-infected. A 5% rate of hepatitis B/HIV co-infection is a reason to increase the accessibility of tenofovir/emtricitabine (Truvada) for first-line treatment for this population.

• Authors: Cynthia Firnhaber, Anne Reyneke, Doreen Schulze, Babatyi Malope, Mhairi Maskew, Patrick MacPhail, Ian Sanne, Adrian Di Bisceglie
• Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (S Afr Med J) Vol. 98 Issue 7 Pg. 541-4 (Jul 2008) ISSN: 0256-9574 [Print] South Africa
• PMID: 18785395 (Publication Type: Journal Article)

Chemical References

• Hepatitis B Surface Antigens

Topics

• Adult
• Ambulatory Care Facilities (statistics & numerical data)
• Comorbidity
• Female
• HIV Infections (epidemiology, physiopathology)
• Hepatitis B (epidemiology, immunology, physiopathology)
• Hepatitis B Surface Antigens (blood)
• Humans
• Male
• Prevalence
• Prognosis
• Prospective Studies
• Risk Assessment
• Risk Factors
• South Africa (epidemiology)
• Urban Population (statistics & numerical data)