Abstract | OBJECTIVES: METHODS AND RESULTS:
NGF levels in BALF from 56 patients with active sarcoidosis (22 with Löfgren's syndrome), nine subjects with resolved sarcoidosis, six patients with CBD, and 31 healthy subjects were compared. A 10-fold elevation of NGF levels was found in patients with active sarcoidosis compared with subjects with clinically resolved sarcoidosis, patients with CBD and healthy subjects. In sarcoidosis patients, positive correlations between concentrations of NGF and lymphocytes, eosinophils and interferon-gamma, interleukin (IL)-4, IL-10, IL-12 were found. CONCLUSIONS:
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Authors | C Dagnell, J Grunewald, F Idali, M Wikén, C Kemi, C M Sköld, A Planck, L S Newman, A Eklund, C Olgart Höglund |
Journal | Journal of internal medicine
(J Intern Med)
Vol. 264
Issue 5
Pg. 463-71
(Nov 2008)
ISSN: 1365-2796 [Electronic] England |
PMID | 18783477
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Interleukin-10
- Interleukin-12
- Interleukin-4
- Interferon-gamma
- Nerve Growth Factor
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Topics |
- Acute Disease
- Adult
- Berylliosis
(metabolism)
- Biomarkers
(analysis)
- Bronchoalveolar Lavage Fluid
(chemistry)
- Case-Control Studies
- Eosinophils
- Female
- Humans
- Interferon-gamma
(analysis)
- Interleukin-10
(analysis)
- Interleukin-12
(analysis)
- Interleukin-4
(analysis)
- Lymphocyte Count
- Male
- Middle Aged
- Nerve Growth Factor
(analysis)
- Sarcoidosis, Pulmonary
(immunology, metabolism)
- Statistics, Nonparametric
- Young Adult
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