Macular structure and vision of patients with macular heterotopia secondary to retinopathy of prematurity.

Abstract

PURPOSE:

To examine if vision in subjects with macular heterotopia (MH) secondary to retinopathy of prematurity (ROP) is related to anatomical macular structure.

METHODS:

Six subjects with MH who were between 18 years and 65 years of age and three age-matched subjects with normal vision were recruited for the study. Vision and macular structure of the better eye of the subjects with MH and the dominant eye of age-matched subjects with normal vision were assessed. High contrast visual acuity and contrast sensitivity were measured using Early Treatment of Diabetic Retinopathy Study and Pelli-Robson charts, respectively. The Micro Perimeter (Nidek Technologies MP-1) was used to assess macular sensitivity and fixation stability. Using optical coherence tomography, macular thickness and relative retinal thickness at fixation were measured.

RESULTS:

Subjects with MH had significantly reduced visual acuity and macular sensitivity compared with age-matched subjects with normal vision. In comparison with their age-matched counterparts, subjects with MH had significantly increased macular thickness and increased relative retinal thickness at fixation. A normal foveal architecture was absent in three subjects with MH (50%).

CONCLUSION:

Patients with MH secondary to ROP have increased macular thickness and reduced vision.

• Authors: Grace P Soong, Michael Shapiro, William Seiple, Janet P Szlyk
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 28 Issue 8 Pg. 1111-6 (Oct 2008) ISSN: 1539-2864 [Electronic] United States
• PMID: 18779718 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Topics

• Adolescent
• Adult
• Aged
• Choristoma (complications, etiology, pathology, physiopathology)
• Fovea Centralis (pathology)
• Humans
• Infant, Newborn
• Macula Lutea (pathology, physiopathology)
• Middle Aged
• Retinal Diseases (complications, etiology, pathology, physiopathology)
• Retinopathy of Prematurity (complications)
• Vision, Low (etiology, physiopathology)
• Visual Acuity
• Young Adult