[A comparative study of intra-arterial infusion chemotherapy and systemic chemotherapy in the treatment of locally advanced breast cancer].

Abstract

A comparative randomized study of intra-arterial infusion chemotherapy (IA) and systemic chemotherapy (IV) was carried out on 41 patients with locally advanced breast cancer, and the following results were obtained. 1) The response rate of primary lesions to IA (63.2%) was better than that of IV (40.9%). 2) In the patients treated with IA, grade of leukopenia, as well as the percentage of gastro-intestinal disorders, was low. 3) More prolonged follow-up studies are required on the therapeutic effects on micrometastasis. The author confirmed that IA was an efficacious neoadjuvant therapy in terms of down staging of locally advanced breast cancer.

• Authors: Y Takatsuka, T Kawahara, E Yayoi, J Okamura, K Miyauchi, E Shiba, T Mori
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 18 Issue 11 Pg. 1740-3 (Aug 1991) ISSN: 0385-0684 [Print] Japan
• PMID: 1877813 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial, Review)

Chemical References

• Epirubicin

Topics

• Breast Neoplasms (drug therapy, pathology)
• Drug Administration Schedule
• Epirubicin (administration & dosage, adverse effects)
• Female
• Humans
• Infusions, Intra-Arterial
• Menopause
• Middle Aged
• Neoplasm Staging