Antisense inhibition of ICAM-1 expression as therapy provides insight into basic inflammatory pathways through early experiences in IBD.

Abstract

BACKGROUND:

Alicaforsen (ISIS 2302), an antisense to intercellular adhesion molecule-1 (ICAM-1) (CD54), was designed to inhibit ICAM-1 expression. ICAM-1 seems to play a role in cell-mediated inflammation, specifically cell trafficking. For this reason, it may be useful in a variety of immune-mediated diseases, including inflammatory bowel disease.

OBJECTIVE:

To evaluate the use of alicaforsen in clinical trials to understand its efficacy and side effects, as well as assess for evidence that may offer insight into disease pathways.

METHODS:

We evaluate all of the available, published trials, with a focus on the prospective, randomized trials.

RESULTS/CONCLUSIONS:

Systemic treatment for Crohn's disease has not revealed significant effect. Topical enemas for ulcerative colitis have demonstrated some effect in secondary outcomes, and initial studies in pouchitis are promising. In general, the compound has been well tolerated and safe.

• Authors: Jessica R Philpott, Philip B Miner Jr
• Journal: Expert opinion on biological therapy (Expert Opin Biol Ther) Vol. 8 Issue 10 Pg. 1627-32 (Oct 2008) ISSN: 1744-7682 [Electronic] England
• PMID: 18774928 (Publication Type: Journal Article)

Chemical References

• Oligonucleotides, Antisense
• Phosphorothioate Oligonucleotides
• Intercellular Adhesion Molecule-1
• alicaforsen

Topics

• Clinical Trials as Topic
• Humans
• Inflammatory Bowel Diseases (drug therapy)
• Intercellular Adhesion Molecule-1 (metabolism)
• Oligonucleotides, Antisense (therapeutic use)
• Phosphorothioate Oligonucleotides (therapeutic use)