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Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy.

Abstract
We report on the outcome of intravenous high-dose immunoglobulin (IVIg) treatment in four children with narcolepsy and cataplexy, in whom the early diagnosis and the extreme disease severity were indications for this potentially efficacious therapy. One of four patients showed an objective and persistent improvement in clinical features during and after IVIg treatment. Our data partially support the recent report of the efficacy of IVIg treatment in early diagnosed narcolepsy with cataplexy and support the need for a controlled multicenter clinical trial on IVIg in narcolepsy.
AuthorsGiuseppe Plazzi, Francesca Poli, Christian Franceschini, Antonia Parmeggiani, Piero Pirazzoli, Filippo Bernardi, Emmanuel Mignot, Alessandro Cicognani, Pasquale Montagna
JournalJournal of neurology (J Neurol) Vol. 255 Issue 10 Pg. 1549-54 (Oct 2008) ISSN: 0340-5354 [Print] Germany
PMID18769859 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunoglobulins, Intravenous
Topics
  • Adolescent
  • Body Mass Index
  • Cataplexy (therapy)
  • Child
  • Circadian Rhythm
  • Female
  • Hallucinations
  • Humans
  • Immunoglobulins, Intravenous (administration & dosage, therapeutic use)
  • Male
  • Narcolepsy (therapy)
  • Severity of Illness Index
  • Sleep
  • Sleep Paralysis

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