Abstract | PURPOSE: MATERIALS/METHODS: Eligibility included biopsy proven rectal adenocarcinoma; T3-T4 N0-N2; performance status < 2 (ECOG) and adequate blood, hepatic and renal function. Treatment consisted of radiotherapy 54 Gy at 1.8 Gy/day and UFT 300 mg/m(2)/day and LV 60 mg/day, given simultaneously daily for 6 weeks. Surgery was performed within 4-6 weeks period after chemoradiotherapy. Patients who did not achieve TGR1 were to receive 4 cycles of adjuvant UFT/LV on days 1-28, every 5 weeks. RESULTS: Sixty-eight patients were included. All but one received full dose of radiation and 62 had the total planned pre-operative UFT/LV dose. Grade 3 toxicities were diarrhea 7% and proctitis 3%. Complete resection was achieved in 62 patients (91%). Tumor regression grade 1 (TRG1) was seen in 11 patients (16%). Forty-eight patients received adjuvant UFT/LV. Grade 3 toxicity during adjuvant UFT/LV included diarrhea 12%, asthenia 4%, neutropenia 2%, and hand-foot syndrome 2%. The 3-year disease-free survival was 71%. CONCLUSIONS: Simultaneous high-dose pre-operative localized radiation therapy concurrent with UFT/LV is feasible and has a low toxicity profile. This schedule is highly effective and merits further investigation.
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Authors | Jordi Giralt, Josep Tabernero, Begoña Navalpotro, Jaume Capdevila, Eloi Espin, Esther Casado, Anabel Mañes, Stefania Landolfi, Jose Luis Sanchez-Garcia, Ines de Torres, Manel Armengol |
Journal | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
(Radiother Oncol)
Vol. 89
Issue 3
Pg. 263-9
(Dec 2008)
ISSN: 0167-8140 [Print] Ireland |
PMID | 18768230
(Publication Type: Clinical Trial, Phase II, Journal Article)
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Chemical References |
- Tegafur
- Uracil
- Leucovorin
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Topics |
- Adenocarcinoma
(radiotherapy, therapy)
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage)
- Combined Modality Therapy
- Female
- Humans
- Leucovorin
(administration & dosage)
- Male
- Middle Aged
- Rectal Neoplasms
(radiotherapy, therapy)
- Tegafur
(administration & dosage)
- Treatment Outcome
- Uracil
(administration & dosage)
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