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Persistent monoclonality after histological remission in gastric mucosa-associated lymphoid tissue lymphoma treated with chemotherapy and/or surgery: influence of t(11;18)(q21;q21).

Abstract
The purpose of this work was to study retrospectively the molecular response and outcome of 19 gastric mucosa associated lymphoid tissue (MALT) lymphoma patients achieving histological remission after chemotherapy or surgery. Immunoglobulin heavy chain variable (IgV(H)) gene rearrangements were studied by PCR in biopsies obtained at diagnosis and follow-up. Presence of t(11;18)(q21;q21) was studied by FISH or RT-PCR. Sequencing analysis of three t(11;18)(q21;q21) positive and two negative lymphomas with persistent monoclonal IgV(H) rearrangements was also performed. Long-term IgV(H) monoclonality was demonstrated in 11/19 patients (58%); in five of them monoclonal rearrangements were present in all samples throughout the follow-up. Persistent IgV(H) monoclonality was detected a median of 49 months after the achievement of histological response and did not condition histological relapse in most cases. All three t(11;18)(q21;q21) positive patients had maintained IgV(H) monoclonality and sequencing analyses revealed the same mutated IgV(H) alleles in the diagnostic and the follow-up samples. Over half of the patients with gastric MALT lymphoma with histological response after chemotherapy and/or surgery have long-term persistent monoclonality. The presence of t(11;18)(q21;q21) seems to condition long-term persistence of the initial lymphoma clone.trade mark.
AuthorsAlmudena Santón, Mónica García-Cosio, Beatriz Bellosillo, Patricia Rodríguez, Eva Cristóbal, Sergio Serrano, Carlos Besses, Victor Abraira, Antonio Salar, Carlos Montalbán
JournalLeukemia & lymphoma (Leuk Lymphoma) Vol. 49 Issue 8 Pg. 1516-22 (Aug 2008) ISSN: 1029-2403 [Electronic] United States
PMID18766964 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • Immunoglobulin Fragments
Topics
  • Chromosomes, Human, Pair 11
  • Chromosomes, Human, Pair 18
  • Clone Cells (pathology)
  • Gene Rearrangement
  • Humans
  • Immunoglobulin Fragments (genetics)
  • Lymphoma, B-Cell, Marginal Zone (genetics, pathology, therapy)
  • Prognosis
  • Remission Induction
  • Retrospective Studies
  • Stomach Neoplasms (genetics, pathology, therapy)
  • Survivors
  • Translocation, Genetic

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