Abstract |
The purpose of this work was to study retrospectively the molecular response and outcome of 19 gastric mucosa associated lymphoid tissue ( MALT) lymphoma patients achieving histological remission after chemotherapy or surgery. Immunoglobulin heavy chain variable (IgV(H)) gene rearrangements were studied by PCR in biopsies obtained at diagnosis and follow-up. Presence of t(11;18)(q21;q21) was studied by FISH or RT-PCR. Sequencing analysis of three t(11;18)(q21;q21) positive and two negative lymphomas with persistent monoclonal IgV(H) rearrangements was also performed. Long-term IgV(H) monoclonality was demonstrated in 11/19 patients (58%); in five of them monoclonal rearrangements were present in all samples throughout the follow-up. Persistent IgV(H) monoclonality was detected a median of 49 months after the achievement of histological response and did not condition histological relapse in most cases. All three t(11;18)(q21;q21) positive patients had maintained IgV(H) monoclonality and sequencing analyses revealed the same mutated IgV(H) alleles in the diagnostic and the follow-up samples. Over half of the patients with gastric MALT lymphoma with histological response after chemotherapy and/or surgery have long-term persistent monoclonality. The presence of t(11;18)(q21;q21) seems to condition long-term persistence of the initial lymphoma clone.trade mark.
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Authors | Almudena Santón, Mónica García-Cosio, Beatriz Bellosillo, Patricia Rodríguez, Eva Cristóbal, Sergio Serrano, Carlos Besses, Victor Abraira, Antonio Salar, Carlos Montalbán |
Journal | Leukemia & lymphoma
(Leuk Lymphoma)
Vol. 49
Issue 8
Pg. 1516-22
(Aug 2008)
ISSN: 1029-2403 [Electronic] United States |
PMID | 18766964
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 18
- Clone Cells
(pathology)
- Gene Rearrangement
- Humans
- Immunoglobulin Fragments
(genetics)
- Lymphoma, B-Cell, Marginal Zone
(genetics, pathology, therapy)
- Prognosis
- Remission Induction
- Retrospective Studies
- Stomach Neoplasms
(genetics, pathology, therapy)
- Survivors
- Translocation, Genetic
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