Abstract | OBJECTIVE: To explore the safe and effective method of hemostasis in laparoscopic hysteromyomectomy (LM). METHODS: Two hundred and eighty women with symptomatic uterine intramural fibroids undergoing LM were assigned to 4 groups, Group A undergoing fibroid pedicle ligation, Group B injected with 12 IU diluted vasopressin around the myoma, Group C injected with 20 IU oxytocin combined with pedicle ligation, and Group D injected with vasopressin combined with pedicle ligation. The operation time, amount of blood loss, operative complications, bowel deflation, post-operative hemoglobin dropping, and length of hospital stay were compared. RESULTS: The amounts of blood loss of Groups A and C were (171 +/- 146) ml and (184 +/- 140) ml, both significantly higher than those of Groups B and D [(115 +/- 70) ml and (106 +/- 73) ml, both P < 0.01]. The length of hospital stay of Group D was (2.9 +/- 0.5) d, significantly shorter than those of Groups A, B, and C [(3.1 +/- 0.7) d, (3.6 +/- 0.8) d, and (3.3 +/- 0.7) d, all P < 0.05]. The bowel deflation time of Group D was (20 +/- 6) h, significantly shorter than those of the Groups A, B, and C [(26 +/-) h, (25 +/- 7) h, and (25 +/- 8) h respectively, all P < 0.05]. The post-operative hemoglobin dropping of group D was (1.1 +/- 0.9) g/L, significantly less than those of Groups A, B, and C [(1.5 +/- 1.0), (1.4 +/- 0.8), and (1.2 +/- 0.7) g/L respectively, all P < 0.05]. CONCLUSIONS:
Vasopressin (12 IU) injection around the myoma is a simple, effective, and safe homeostatic procedure during LM. Pedicle ligation can reduce advanced post-operative bleeding post-operation.
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Authors | Xiao-Na Lin, Song-Ying Zhang, Su-Hua Fang, Min-Zhen Wang, Hong-Ying Lou |
Journal | Zhonghua yi xue za zhi
(Zhonghua Yi Xue Za Zhi)
Vol. 88
Issue 13
Pg. 905-8
(Apr 01 2008)
ISSN: 0376-2491 [Print] China |
PMID | 18756957
(Publication Type: English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hemostatics
- Oxytocics
- Vasopressins
- Oxytocin
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Topics |
- Adult
- Combined Modality Therapy
- Female
- Gynecologic Surgical Procedures
(methods)
- Hemostatic Techniques
- Hemostatics
(administration & dosage, therapeutic use)
- Humans
- Laparoscopy
- Leiomyoma
(therapy)
- Myoma
(therapy)
- Oxytocics
(administration & dosage, therapeutic use)
- Oxytocin
(administration & dosage, therapeutic use)
- Postoperative Hemorrhage
(prevention & control)
- Treatment Outcome
- Uterine Neoplasms
(therapy)
- Vasopressins
(administration & dosage, therapeutic use)
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