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[Humoral response to hepatitis C virus antigens in coinfection with human immunodeficiency virus type 1].

Abstract
A humoral immune response to individual hepatitis C virus (HCV) antigens was studied in 49 patients at the subclinical stage of HIV-1 infection. These patients, as compared with a group comprising 50 patients with chronic hepatitis C, showed statistically significant higher levels of HCV-specific immunoglobulins G to nucleocapsid protein and the antigens NS3, NS4ab, NS5a. The group of patients with coinfection did not differ from those with chronic HCV monoinfection in detection rates and anti-HCV IgM.
AuthorsL I Nikolaeva, S Ia Zverev, E V Petrova, E I Samokhvalov, S V Al'khovskiĭ, A K Tokmalaev, E V Kazennova, M R Bobkova
JournalKlinicheskaia laboratornaia diagnostika (Klin Lab Diagn) Issue 7 Pg. 42-4 (Jul 2008) ISSN: 0869-2084 [Print] Russia (Federation)
PMID18756735 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Hepatitis C Antigens
Topics
  • Adult
  • Antibody Formation
  • Female
  • HIV Infections (complications, immunology)
  • HIV-1
  • Hepacivirus (immunology)
  • Hepatitis C Antigens (immunology)
  • Hepatitis C, Chronic (complications, immunology)
  • Humans
  • Male

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