Expression transformation of claudin-1 in the process of gastric adenocarcinoma invasion.

Abstract

AIM:

To investigate the relation of expression transformation of claudin-1 with invasiveness and metastasis of gastric carcinoma.

METHODS:

By using immunohistochemistry, expression of claudin-1 in mucosa and invasive front of 136 gastric adenocarcinoma cases and proliferative index (Ki-67) were detected and analyzed.

RESULTS:

In mucosa, the claudin-1 over-expression rate of mucinous adenocarcinomas (including signet-ring cell carcinomas) was the highest. It was negatively related with the differentiation but positively related with the invasiveness and metastasis of gastric cancer. In invasive front, the claudin-1 over-expression rate was positively related with the differentiation, invasiveness and metastasis of gastric carcinoma. The expression transformation of claudin-1 was found in gastric carcinoma. The expression of claudin-1 in invasive front was transformed in 28/136 gastric carcinoma cases. The transformation rate in highly differentiated tubular adenocarcinomas was the highest (51.5%, 17/33). The deeper was the invasiveness, the higher was the transformation rate. The claudin-1 expression transformation rate in serosa and omenta was significantly higher (92.9%) than in tunica muscularis of invasive gastric cancer cases, as well as in patients with lymph node metastasis than in those without lymph node metastasis.

CONCLUSION:

Up-regulation of claudin-1 expression and its transformation in invasive and metastatic gastric carcinoma suggest that claudin-1 participates in the transformation of biological behaviors in neoplasms. Further study is needed to elucidate the precise mechanism and the relation of claudin-1 expression with the neoplasm progress.

• Authors: Yong-Lian Wu, Sheng Zhang, Guo-Rong Wang, Yu-Peng Chen
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 14 Issue 31 Pg. 4943-8 (Aug 21 2008) ISSN: 1007-9327 [Print] United States
• PMID: 18756604 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CLDN1 protein, human
• Claudin-1
• Membrane Proteins

Topics

• Adenocarcinoma (chemistry, pathology)
• Adult
• Aged
• Aged, 80 and over
• Cell Differentiation
• Cell Proliferation
• Claudin-1
• Female
• Gastric Mucosa (chemistry, pathology)
• Humans
• Immunohistochemistry
• Male
• Membrane Proteins (analysis)
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Metastasis
• Stomach Neoplasms (chemistry, pathology)
• Up-Regulation