It is well known that urinary
FDP is one of the parameters of intrarenal coagulation in renal disease. The measurement of urinary
FDP, however, is not satisfactory enough, since it is not a quantitative and sensitive method.
Latex photometric immunoassay has recently been developed as a quantitative and more sensitive method. Since
fibrinogen reacts with
FDP-E less than
FDP, the measurement of urinary
FDP-E is much better than that of urinary
FDP in order to determine the presence of intrarenal coagulation and fibrinolysis of patients with renal diseases. The aim of this study is to clarify the clinical significance of urinary
FDP-E measured by LPIA in the renal disease. The results were as follows: (1) Urinary
FDP-E correlate with urinary
protein,
FDP,
FDP-D,
fibrinopeptide A (FPA), but not serum
FDP-E. (2) The diseases which showed higher amounts of urinary
FDP-E were
diabetic nephropathy,
amyloidosis and chronic
glomerulonephritis. On the other hand, the diseases which showed smaller amounts of urinary
FDP-E were minimal change,
toxemia of pregnancy and
lupus nephritis. All patients with higher amounts of urinary
FDP-E showed marked renal dysfunction. But all the patients with the marked renal dysfunction did not always show higher amounts of urinary
FDP-E. The urinary
FDP-E showed a positive correlation to 1/serum
creatinine. These results suggested that the measurement of urinary
FDP-E is a useful method in determining the presence and degree of intrarenal coagulation and fibrinolysis in renal diseases.