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Correlation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn's disease and histological findings.

AbstractBACKGROUND:
Faecal calprotectin and lactoferrin increasingly serve as surrogate markers of disease activity in IBD. Data on the correlation of these markers with simple endoscopic score for Crohn's disease (SES-CD) and with histological findings are as yet limited. Aim To study the correlation of faecal calprotectin and lactoferrin with SES-CD and histology.
METHODS:
During 87 consecutive ileocolonoscopies, SES-CD was calculated and biopsy specimens were obtained from the ileum, colon and rectum. Faecal calprotectin and lactoferrin were measured.
RESULTS:
In ileocolonic or colonic disease, both faecal calprotectin and lactoferrin correlated significantly with colon SES-CD (P < 0.001) and colon histology (P < 0.001). In patients with normal calprotectin or lactoferrin levels, endoscopic and histology scores were significantly lower than in those with elevated concentrations (P < 0.001). In ileal CD, ileal SES-CD correlated with histology (P < 0.001), but not with faecal calprotectin (P = 0.161) or lactoferrin (P = 0.448).
CONCLUSION:
In ileocolonic and colonic disease, endoscopic score SES-CD and histological findings correlated significantly with faecal calprotectin and lactoferrin. A normal faecal-marker concentration was a reliable surrogate marker for endoscopically and histologically inactive CD. Ileal endoscopic score and histological findings failed, however, to correlate with faecal markers.
AuthorsT Sipponen, P Kärkkäinen, E Savilahti, K-L Kolho, H Nuutinen, U Turunen, M Färkkilä
JournalAlimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 28 Issue 10 Pg. 1221-9 (Nov 15 2008) ISSN: 1365-2036 [Electronic] England
PMID18752630 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers
  • Leukocyte L1 Antigen Complex
  • Lactoferrin
Topics
  • Adult
  • Aged
  • Biomarkers
  • Crohn Disease (diagnosis, pathology)
  • Endoscopy, Gastrointestinal
  • Feces (chemistry)
  • Female
  • Humans
  • Lactoferrin (analysis)
  • Leukocyte L1 Antigen Complex (analysis)
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Severity of Illness Index
  • Statistics as Topic
  • Young Adult

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