Abstract | BACKGROUND: METHODS: During 87 consecutive ileocolonoscopies, SES-CD was calculated and biopsy specimens were obtained from the ileum, colon and rectum. Faecal calprotectin and lactoferrin were measured. RESULTS: In ileocolonic or colonic disease, both faecal calprotectin and lactoferrin correlated significantly with colon SES-CD (P < 0.001) and colon histology (P < 0.001). In patients with normal calprotectin or lactoferrin levels, endoscopic and histology scores were significantly lower than in those with elevated concentrations (P < 0.001). In ileal CD, ileal SES-CD correlated with histology (P < 0.001), but not with faecal calprotectin (P = 0.161) or lactoferrin (P = 0.448). CONCLUSION: In ileocolonic and colonic disease, endoscopic score SES-CD and histological findings correlated significantly with faecal calprotectin and lactoferrin. A normal faecal-marker concentration was a reliable surrogate marker for endoscopically and histologically inactive CD. Ileal endoscopic score and histological findings failed, however, to correlate with faecal markers.
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Authors | T Sipponen, P Kärkkäinen, E Savilahti, K-L Kolho, H Nuutinen, U Turunen, M Färkkilä |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 28
Issue 10
Pg. 1221-9
(Nov 15 2008)
ISSN: 1365-2036 [Electronic] England |
PMID | 18752630
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Leukocyte L1 Antigen Complex
- Lactoferrin
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Topics |
- Adult
- Aged
- Biomarkers
- Crohn Disease
(diagnosis, pathology)
- Endoscopy, Gastrointestinal
- Feces
(chemistry)
- Female
- Humans
- Lactoferrin
(analysis)
- Leukocyte L1 Antigen Complex
(analysis)
- Male
- Middle Aged
- Predictive Value of Tests
- Severity of Illness Index
- Statistics as Topic
- Young Adult
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