This study was designed to evaluate the efficacy of
gabapentin (GBP) in the treatment of
SUNCT syndrome on a relatively large sample of Persian patients. Eight patients with
SUNCT syndrome underwent a 4-week, open-label, daily treatment of 600-900 mg GBP. The frequency, intensity and duration of attacks were compared before and after the trial. After 4 weeks of treatment, intensity, duration and frequency of
headaches were significantly (P < 0.05) reduced. In addition, five patients (62.5%) were completely relieved from
headaches, and in the other three patients the mean intensity, frequency and duration of
headaches were decreased notably. In this study, GBP was well tolerated and no unfavourable side-effects were reported. After the end of the trial all patients continued the medication, and after 3 months none reported undesired side-effects or return of the
headaches to the pre-treatment status. Our patients had a significant response to GBP, and considering other case reports on the effectiveness of GBP in the treatment of
SUNCT syndrome, we propose that, taking into account the good side-effect profile and lack of interactions of GBP, this
drug could be considered as an option for the treatment of SUNCT.