Abstract |
The authors have shown the activity of argyrophylic nucleolar organizer region proteins ( Ag-NOR-proteins) in the uterine leiomyomas of varying histological structure and determined their relationship to the growth rate, size, and site of a node and endometrial pathology. The investigation indicat yomas with significant sclerosis, 4.32 +/- 0.1 in simple leiomyomas, and 6.2 +/- 0.2 in cell leiomyomas (r = 0.58). In menopause, myomas with significant sclerosis and hyalinosis were characterized with a small number of Ag-NOR (1.44 +/- 0.04). Thus, the organizers numbered 12.1 +/- 0.5 and 21.7 +/- 1.0 in high- and low-grade sarcomas, respectively, which may be used in the differential diagnosis of cellular, bizarre, mitotically active leiomyomas and leiomyosarcomas.
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Authors | I P Bobrov, A M Avdalian, A F Lazarev, V V Klimachev, T B Klimacheva, E V Mishchenko |
Journal | Arkhiv patologii
(Arkh Patol)
2008 May-Jun
Vol. 70
Issue 3
Pg. 18-23
ISSN: 0004-1955 [Print] Russia (Federation) |
PMID | 18727427
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Neoplasm Proteins
- Nuclear Proteins
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Topics |
- Adult
- Diagnosis, Differential
- Female
- Follicular Phase
(metabolism)
- Humans
- Leiomyoma
(metabolism, pathology)
- Leiomyosarcoma
(metabolism, pathology)
- Luteal Phase
(metabolism)
- Menopause
(metabolism)
- Middle Aged
- Myoma
(metabolism, pathology)
- Neoplasm Proteins
(metabolism)
- Nuclear Proteins
(metabolism)
- Nucleolus Organizer Region
(metabolism, pathology)
- Sclerosis
- Uterine Neoplasms
(metabolism, pathology)
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