Abstract | BACKGROUND: METHODS AND RESULTS: Rats were treated with oral BH4 supplementation starting at 3 days before coronary artery ligation. At 4 weeks after MI, there was augmented superoxide production in association with reduced BH4/ dihydrobiopterin (BH2) ratio and eNOS dimer/monomer protein ratio in the heart. Treatment with BH4 increased BH4/BH2 ratio and eNOS dimer/monomer ratio, and decreased superoxide production. In BH4-treated MI rats, left ventricular size was smaller, thickness of the non-infarcted posterior wall was thinner, and cardiac function was preserved compared with the control MI rats. CONCLUSIONS: The present study suggested that ventricular remodeling process after MI leads to BH4 oxidation and resulted in uncoupled eNOS-derived superoxide generation, which further augmented the remodeling process and deteriorated cardiac function.
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Authors | Tomoya Masano, Seinosuke Kawashima, Ryuji Toh, Seimi Satomi-Kobayashi, Masakazu Shinohara, Tomofumi Takaya, Naoto Sasaki, Masafumi Takeda, Hideto Tawa, Tomoya Yamashita, Mitsuhiro Yokoyama, Ken-ichi Hirata |
Journal | Circulation journal : official journal of the Japanese Circulation Society
(Circ J)
Vol. 72
Issue 9
Pg. 1512-9
(Sep 2008)
ISSN: 1346-9843 [Print] Japan |
PMID | 18724032
(Publication Type: Journal Article)
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Chemical References |
- Superoxides
- Biopterin
- Nitric Oxide Synthase Type III
- Nos3 protein, rat
- sapropterin
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Topics |
- Animals
- Biopterin
(analogs & derivatives, pharmacology)
- Male
- Myocardial Infarction
(enzymology)
- Nitric Oxide Synthase Type III
(metabolism)
- Oxidation-Reduction
(drug effects)
- Oxidative Stress
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Superoxides
(metabolism)
- Ventricular Remodeling
(drug effects)
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