Neuroprotective effects of vitamin E on adult rat motor neurones following facial nerve avulsion.

Abstract

CONCLUSION:

The present study demonstrates the neuroprotective effect of vitamin E after peripheral facial nerve injury. Antioxidants may have therapeutic potential in traumatic facial nerve dysfunction resulting from traumatic temporal bone injury and ear surgery.

OBJECTIVE:

We investigated the possible neuroprotective effect of vitamin E on the facial motor nucleus (FMN) motor neurones after peripheral nerve avulsion.

METHODS:

In 36 adult rats, the right facial nerve was avulsed from the stylomastoid foramen. Following nerve avulsion, immunohistochemistry was used to investigate the effects of vitamin E on 4-hydroxynonenal (HNE) activity. FMN motor neurones and glial cells were counted bilaterally in sections stained with cresyl violet.

RESULTS:

Rats administered vitamin E exhibited clear suppression of injury-induced neuronal HNE expression in the ipsilateral FMN as compared to non-treated controls. Following nerve avulsion, the number of surviving motor neurones in the ipsilateral FMN was significantly greater among vitamin E-treated rats than non-treated controls.

• Authors: Shigeru Hoshida, Miyako Hatano, Mitsuru Furukawa, Makoto Ito
• Journal: Acta oto-laryngologica (Acta Otolaryngol) Vol. 129 Issue 3 Pg. 330-6 (Mar 2009) ISSN: 1651-2251 [Electronic] England
• PMID: 18720077 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aldehydes
• Neuroprotective Agents
• Vitamin E
• 4-hydroxy-2-nonenal

Topics

• Aldehydes (metabolism)
• Animals
• Cell Count
• Cell Proliferation (drug effects)
• Dose-Response Relationship, Drug
• Facial Nerve Injuries
• Immunohistochemistry
• Male
• Motor Neurons (drug effects, metabolism)
• Neuroglia (drug effects, metabolism)
• Neuroprotective Agents (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Vitamin E (pharmacology)