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Solitary pleural plasmacytomas manifested as a massive pleural effusion without evidence of monoclonal gammopathy.

Abstract
The majority of extramedullary plasmacytomas involve the upper respiratory tract but only a few are associated with serum monoclonal gammopathy. Most extramedullary plasmacytomas respond to local radiotherapy and have a better prognosis than multiple myeloma. Solitary plasmacytomas, involving the pleura, are very rare. This case report describes a patient with a solitary extramedullary plasmacytoma involving the pleura, and no evidence of serum, urine or pleural fluid paraproteins. Diagnosis was made by strongly positive immunohistochemical stains with CD38, CD138 and MUM-1 of the pleural tumour. The response to both radiotherapy and chemotherapy was poor and the patient died shortly after diagnosis.
AuthorsPo Hao Feng, Chung-Chi Huang, Chih-Wei Wang, Yao-Kuang Wu, Ying-Huang Tsai
JournalRespirology (Carlton, Vic.) (Respirology) Vol. 13 Issue 5 Pg. 751-3 (Sep 2008) ISSN: 1440-1843 [Electronic] Australia
PMID18713097 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Interferon Regulatory Factors
  • Paraproteins
  • Syndecan-1
  • interferon regulatory factor-4
  • ADP-ribosyl Cyclase 1
Topics
  • ADP-ribosyl Cyclase 1 (metabolism)
  • Adult
  • Humans
  • Interferon Regulatory Factors (metabolism)
  • Lung (diagnostic imaging, metabolism)
  • Male
  • Paraproteinemias (diagnosis, metabolism)
  • Paraproteins (metabolism)
  • Plasmacytoma (diagnosis, metabolism, therapy)
  • Pleural Effusion, Malignant (diagnosis, metabolism)
  • Pleural Neoplasms (diagnosis, metabolism, therapy)
  • Radiography, Thoracic
  • Syndecan-1 (metabolism)

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