Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer.

Abstract

The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell growth, death, motility, and tissue remodeling. Among the six IGFBP family members, IGFBP-5 has recently been shown to play an important role in the biology of breast cancer, especially in breast cancer metastasis; however, the exact mechanisms of action remain obscure and sometimes paradoxical. An in-depth understanding of IGFBP-5 would shed light on its potential role as a target for breast cancer therapeutics.

• Authors: Mustafa Akkiprik, Yumei Feng, Huamin Wang, Kexin Chen, Limei Hu, Aysegul Sahin, Savitri Krishnamurthy, Ayse Ozer, Xishan Hao, Wei Zhang
• Journal: Breast cancer research : BCR (Breast Cancer Res) Vol. 10 Issue 4 Pg. 212 ( 2008) ISSN: 1465-542X [Electronic] England
• PMID: 18710598 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review)

Chemical References

• Insulin-Like Growth Factor Binding Protein 5
• Insulin-Like Growth Factor Binding Proteins

Topics

• Animals
• Breast Neoplasms (diagnosis, pathology)
• Cell Proliferation
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Insulin-Like Growth Factor Binding Protein 5 (metabolism)
• Insulin-Like Growth Factor Binding Proteins (metabolism)
• Medical Oncology (methods)
• Mice
• Prognosis
• Protein Structure, Tertiary
• Transcription, Genetic