Glycopeptide insensitive Staphylococcus aureus subdural empyema treated with linezolid and rifampicin.

Abstract

A 4-year-old boy had surgical debulking of a cerebral astrocytoma followed by chemotherapy. He developed a subdural empyema with a teicoplanin and methicillin resistant Staphylococcus aureus. He was successfully treated with surgical drainage and 6 weeks of antibiotic therapy which included linezolid, rifampicin and metronidazole. Linezolid may be successful in treating other CNS infections caused by antibiotic resistant gram-positive organisms.

• Authors: R M Gallagher, B Pizer, J A Ellison, F A I Riordan
• Journal: The Journal of infection (J Infect) Vol. 57 Issue 5 Pg. 410-3 (Nov 2008) ISSN: 1532-2742 [Electronic] England
• PMID: 18703232 (Publication Type: Case Reports, Journal Article)

Chemical References

• Acetamides
• Anti-Infective Agents
• Oxazolidinones
• Teicoplanin
• Linezolid
• Rifampin

Topics

• Acetamides (therapeutic use)
• Anti-Infective Agents (therapeutic use)
• Child, Preschool
• Drainage
• Drug Resistance, Multiple, Bacterial
• Drug Therapy, Combination
• Empyema, Subdural (microbiology, therapy)
• Humans
• Linezolid
• Male
• Methicillin-Resistant Staphylococcus aureus
• Microbial Sensitivity Tests
• Oxazolidinones (therapeutic use)
• Rifampin (therapeutic use)
• Staphylococcal Infections (drug therapy)
• Teicoplanin (therapeutic use)