Abstract | AIM: To determine the efficacy of a combination of Bifidobacterium longum PL03, Lactobacillus rhamnosus KL53A and Lactobacillus plantarum PL02 for the prevention of antibiotic-associated diarrhea in children. METHODS: RESULTS: Patients receiving probiotics had a similar rate of diarrhea (> or =3 loose or watery stools/day for > or =48 h occurring during or up to 2 weeks after the antibiotic therapy) as those receiving placebo (relative risk 0.5, 95% CI 0.06-3.5). The mean number of stools per day was significantly lower in the experimental group (mean difference -0.3 stool/day, 95% CI -0.5 to -0.07). No adverse events were reported. CONCLUSION: The administration of the 3 probiotics did not significantly alter the rate of diarrhea, although it reduced the frequency of stools per day. As the overall frequency of diarrhea was surprisingly low, these results should be interpreted with caution.
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Authors | Henryk Szymański, Małgorzata Armańska, Kinga Kowalska-Duplaga, Hania Szajewska |
Journal | Digestion
(Digestion)
Vol. 78
Issue 1
Pg. 13-7
( 2008)
ISSN: 1421-9867 [Electronic] Switzerland |
PMID | 18701826
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | 2008 S. Karger AG, Basel. |
Chemical References |
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Topics |
- Adolescent
- Anti-Bacterial Agents
(adverse effects)
- Bifidobacterium
- Child
- Child, Preschool
- Diarrhea
(chemically induced, prevention & control)
- Dietary Supplements
- Double-Blind Method
- Female
- Humans
- Infant
- Lactobacillus plantarum
- Lacticaseibacillus rhamnosus
- Male
- Otitis Media
(drug therapy)
- Pilot Projects
- Probiotics
(therapeutic use)
- Respiratory Tract Infections
(drug therapy)
- Treatment Outcome
- Urinary Tract Infections
(drug therapy)
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