Abstract |
Helicobacter pylori (H. pylori) is a gram negative, spiral, microaerophylic bacterium that infects the stomach of more than 50% of the human population worldwide. H. pylori is well recognized as a critical factor in the majority of patients with peptic ulcer disease and successful treatment results in cure of the disease. On the other hand, H. pylori infection has been associated with several extra- intestinal diseases such as hepatic encephalopathy. In this study, a triple treatment was used in management and eradication of H. pylori infection. We hypothesized that H. pylori infection and/or eradication treatment increased the releasing of alpha- glutathione S-transferase (alpha-GST). We also investigated whether alpha-GST is a more sensitive marker than aminotransferases (traditional liver function tests) for hepatocellular damage. However, we did not find any association between both H. pylori infection and eradication treatment and alpha-GST levels. According to our data, eradication treatment did not cause hepatocellular damage.
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Authors | Bensu Karahalil, Seyhan Yağar, Yasemin Ozin |
Journal | Current drug safety
(Curr Drug Saf)
Vol. 2
Issue 1
Pg. 43-6
(Jan 2007)
ISSN: 1574-8863 [Print] United Arab Emirates |
PMID | 18690949
(Publication Type: Journal Article)
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Chemical References |
- Anti-Infective Agents
- Isoenzymes
- gamma-Glutamyltransferase
- Glutathione Transferase
- glutathione S-transferase alpha
- Aspartate Aminotransferases
- Alanine Transaminase
- Alkaline Phosphatase
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Topics |
- Adolescent
- Adult
- Aged
- Alanine Transaminase
(blood)
- Alkaline Phosphatase
(blood)
- Anti-Infective Agents
(adverse effects, therapeutic use)
- Aspartate Aminotransferases
(blood)
- Enzyme-Linked Immunosorbent Assay
- Female
- Glutathione Transferase
(metabolism)
- Helicobacter Infections
(drug therapy, enzymology, pathology)
- Hepatocytes
(microbiology, pathology)
- Humans
- Isoenzymes
(metabolism)
- Liver Diseases
(drug therapy, enzymology, pathology)
- Liver Function Tests
- Male
- Middle Aged
- gamma-Glutamyltransferase
(blood)
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