Miller-Fisher syndrome associated with chronic lymphocytic leukemia.

Abstract

Chronic lymphocytic leukemia (CLL) is a frequent hematological malignancy, with meningeal or peripheral nerve infiltrations being the most commonly encountered neurological complications. In this report, we describe a CLL patient with Miller-Fisher syndrome (MFS) who responded to immune modulation with plasmapheresis. A 47-year-old man diagnosed as B-cell CLL admitted with neutropenic fever. He complained of diplopia and numbness of both arms. Neurological examination revealed a bilateral external ophthalmoplegia, dysphagia, dysarthria, mild shoulder girdle muscle weakness and gait ataxia, accompanied by absent tendon reflexes. Nerve conduction studies were indicative of a predominantly axonal sensori-motor peripheral neuropathy. This association of CLL with MFS had not been previously reported in the literature.

• Authors: Zeynep Aki, Ozlem Aksoy, Gulsan Sucak, Reha Kuruoğlu, Münci Yağci
• Journal: Neurology India (Neurol India) 2008 Apr-Jun Vol. 56 Issue 2 Pg. 198-200 ISSN: 0028-3886 [Print] India
• PMID: 18688150 (Publication Type: Case Reports, Journal Article)

Topics

• Follow-Up Studies
• Humans
• Leukemia, Lymphocytic, Chronic, B-Cell (complications)
• Male
• Middle Aged
• Miller Fisher Syndrome (complications)
• Neural Conduction (physiology)
• Neurologic Examination
• Peripheral Nerves (physiopathology)