Abstract | OBJECTIVE: METHODS: MMF 2 g/day and prednisone 1 mg/kg were initiated in nine patients with radiological (9/9) and histological verification (2/9) of idiopathic RF. Out of nine patients, seven needed bilateral ureteral stenting due to extensive hydronephrosis. RESULTS: All patients experienced regression of radiological extension. Out of seven patients, five were free of ureteral catheters after a mean of 5.6 months and two remained on stenting due to secondary stenosis. Within 6 months mean creatinine and CRP fell from 2.5 to 1.2 mg/dl and from 4.0 to 1.4 mg/dl, respectively. MMF was discontinued after a mean of 27 months. Prednisone was tapered to zero after a mean of 7 months. Side-effects were urinary tract infections in 7/9 patients and impaired glucose tolerance in 3/9. No recurrence occurred after withdrawal of glucocorticoids and MMF in 7/9 patients after a mean overall follow-up of 55 months (range 12-120). CONCLUSIONS: Treatment with MMF and glucocorticoids was successful in inducing partial or complete and lasting remission in RF. The results suggest the use of MMF as additional immunosuppressive option.
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Authors | S Adler, S Lodermeyer, J Gaa, U Heemann |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 47
Issue 10
Pg. 1535-8
(Oct 2008)
ISSN: 1462-0332 [Electronic] England |
PMID | 18687710
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Glucocorticoids
- Immunosuppressive Agents
- Mycophenolic Acid
- Prednisone
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Topics |
- Adult
- Aged
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Glucocorticoids
(adverse effects, therapeutic use)
- Humans
- Immunosuppressive Agents
(adverse effects, therapeutic use)
- Magnetic Resonance Imaging
(methods)
- Male
- Middle Aged
- Mycophenolic Acid
(adverse effects, analogs & derivatives, therapeutic use)
- Prednisone
(adverse effects, therapeutic use)
- Retroperitoneal Fibrosis
(drug therapy, pathology)
- Treatment Outcome
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