HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Successful mycophenolate mofetil therapy in nine patients with idiopathic retroperitoneal fibrosis.

AbstractOBJECTIVE:
To assess the therapeutic benefit of mycophenolate mofetil (MMF) in retroperitoneal fibrosis (RF).
METHODS:
MMF 2 g/day and prednisone 1 mg/kg were initiated in nine patients with radiological (9/9) and histological verification (2/9) of idiopathic RF. Out of nine patients, seven needed bilateral ureteral stenting due to extensive hydronephrosis.
RESULTS:
All patients experienced regression of radiological extension. Out of seven patients, five were free of ureteral catheters after a mean of 5.6 months and two remained on stenting due to secondary stenosis. Within 6 months mean creatinine and CRP fell from 2.5 to 1.2 mg/dl and from 4.0 to 1.4 mg/dl, respectively. MMF was discontinued after a mean of 27 months. Prednisone was tapered to zero after a mean of 7 months. Side-effects were urinary tract infections in 7/9 patients and impaired glucose tolerance in 3/9. No recurrence occurred after withdrawal of glucocorticoids and MMF in 7/9 patients after a mean overall follow-up of 55 months (range 12-120).
CONCLUSIONS:
Treatment with MMF and glucocorticoids was successful in inducing partial or complete and lasting remission in RF. The results suggest the use of MMF as additional immunosuppressive option.
AuthorsS Adler, S Lodermeyer, J Gaa, U Heemann
JournalRheumatology (Oxford, England) (Rheumatology (Oxford)) Vol. 47 Issue 10 Pg. 1535-8 (Oct 2008) ISSN: 1462-0332 [Electronic] England
PMID18687710 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Glucocorticoids
  • Immunosuppressive Agents
  • Mycophenolic Acid
  • Prednisone
Topics
  • Adult
  • Aged
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Glucocorticoids (adverse effects, therapeutic use)
  • Humans
  • Immunosuppressive Agents (adverse effects, therapeutic use)
  • Magnetic Resonance Imaging (methods)
  • Male
  • Middle Aged
  • Mycophenolic Acid (adverse effects, analogs & derivatives, therapeutic use)
  • Prednisone (adverse effects, therapeutic use)
  • Retroperitoneal Fibrosis (drug therapy, pathology)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: