HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Interference in thyroid-function tests in postpartum thyroiditis.

Abstract
Three women are described from a study of patients with postpartum thyroiditis whose sera gave spuriously increased concentrations of free thyroid hormone because of antibody binding of radiolabeled thyroxin (T4) and triiodothyronine (T3) analogs. All of the women showed increased serum concentrations of thyroid autoantibodies. The antibody binding of radiolabeled analogs and its effect on free T4 and free T3 assays disappeared by 48 weeks postpartum. Postpartum women who develop thyroid autoantibodies have approximately 2% prevalence of increased binding of radiolabeled analogs, which can result in an interference in thyroid hormone assays involving T4 and T3 analogs.
AuthorsR John, S Othman, A B Parkes, J H Lazarus, R Hall
JournalClinical chemistry (Clin Chem) Vol. 37 Issue 8 Pg. 1397-400 (Aug 1991) ISSN: 0009-9147 [Print] England
PMID1868601 (Publication Type: Journal Article)
Chemical References
  • Autoantibodies
  • Triiodothyronine
  • Thyroxine
Topics
  • Autoantibodies (analysis)
  • Female
  • Humans
  • Labor, Obstetric
  • Pregnancy
  • Radioimmunoassay
  • Thyroid Function Tests
  • Thyroid Gland (immunology, physiopathology)
  • Thyroiditis (blood)
  • Thyroxine (metabolism)
  • Triiodothyronine (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: