Abstract | OBJECTIVES: METHODS: Thirty-one female patients with osteoporosis for at least 3 years participated in this study. Eighteen women were taking calcium plus vitamin D plus alendronate, while 13 women were taking only calcium plus vitamin D supplements. Eleven systemically healthy women volunteered for the control group. Whole saliva samples were collected from all women before initiation of any periodontal intervention. Plaque index, probing depth, clinical attachment level, bleeding on probing, and calculus index were recorded at six sites/tooth. Salivary concentrations of ionic calcium, potassium, magnesium and sodium were determined by atomic absorption spectrophotometer. Results were evaluated statistically by non-parametric tests. RESULTS: No significant differences were found in clinical parameters or results of saliva analysis between the study groups (p > 0.05). CONCLUSION: Within the limits of this preliminary study, it is suggested that long-term calcium and vitamin D supplementation with or without alendronate does not appear to have a significant effect on supragingival calculus formation or saliva total calcium, potassium, magnesium and sodium concentrations. Larger-scale studies investigating the possible effects of various treatment modalities of osteoporosis on supragingival calculus formation are required to better clarify this issue.
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Authors | Nurcan Buduneli, Buket Han Saygan, Ural Karaduman, Fulden Saraç, Musa Karaduman, Necmettin Ayçelik |
Journal | Expert opinion on pharmacotherapy
(Expert Opin Pharmacother)
Vol. 9
Issue 12
Pg. 2015-20
(Aug 2008)
ISSN: 1744-7666 [Electronic] England |
PMID | 18671457
(Publication Type: Journal Article)
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Chemical References |
- Bone Density Conservation Agents
- Drug Combinations
- Electrolytes
- Vitamin D
- Calcium
- Alendronate
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Topics |
- Alendronate
(adverse effects, pharmacology)
- Bone Density Conservation Agents
(adverse effects, pharmacology)
- Calcium
(adverse effects, pharmacology)
- Cross-Sectional Studies
- Dental Calculus
(chemistry, etiology)
- Dental Plaque
(chemistry)
- Dental Plaque Index
- Dietary Supplements
- Drug Administration Schedule
- Drug Combinations
- Drug Therapy, Combination
- Electrolytes
(analysis)
- Female
- Humans
- Middle Aged
- Osteoporosis, Postmenopausal
- Saliva
(chemistry, drug effects)
- Spectrophotometry, Atomic
- Vitamin D
(adverse effects, pharmacology)
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