A New TRADDition in intracellular antiviral signaling.

Abstract

To effectively defeat viral infection, a mammalian host must detect the presence of viruses and activate a robust antiviral response, which is mediated by cytokines known as type I interferons (IFNs). Much excitement has been generated by the discovery of the retinoic acid-induced gene 1-like helicase (RLH) pathway, which detects RNA-containing viruses in the cytoplasm and activates the type I IFN response. A study now describes a role for the tumor necrosis factor receptor (TNFR)-associated death domain (TRADD) in the antiviral response and sheds new light on how the RLH signaling complex is organized upon viral infection.

• Authors: Eric M Pietras, Genhong Cheng
• Journal: Science signaling (Sci Signal) Vol. 1 Issue 30 Pg. pe36 (Jul 29 2008) ISSN: 1937-9145 [Electronic] United States
• PMID: 18664658 (Publication Type: Journal Article)

Chemical References

• TNF Receptor-Associated Death Domain Protein

Topics

• Animals
• Humans
• RNA Viruses (physiology)
• Signal Transduction (physiology)
• TNF Receptor-Associated Death Domain Protein (physiology)
• Virus Diseases (prevention & control)