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Myomatous erythrocytosis syndrome: further proof for the pathogenic role of erythropoietin.

AbstractBACKGROUND:
Myomatous erythrocytosis syndrome is defined by the combination of erythrocytosis, myomatous uterus and persistent restoration of normal haematological values after hysterectomy. A pathogenic role of erythropoietin is suggested by clinical and experimental data.
CASE REPORT:
A postmenopausal patient is described with the classical clinical signs of the myomatous erythrocytosis syndrome. During hysterectomy we demonstrated a large gradient between the erythropoietin levels in the uterine vein and artery, providing direct evidence for in vivo erythropoietin production by the myomatous uterus.
CONCLUSION:
While erythropoietin and its receptor are consecutively expressed in normal and myomatous uterine tissue, it is amazing that erythrocytosis occurs so rarely in such a frequent disorder as uterine myomatous. We strongly advocate cytogenetic examination of the myomatous tissue of subsequent patients with this entity.
AuthorsL T Vlasveld, C W M de Wit, R A Verweij, A Castel, P M Jansen, A A W Peters
JournalThe Netherlands journal of medicine (Neth J Med) 2008 Jul-Aug Vol. 66 Issue 7 Pg. 283-5 ISSN: 0300-2977 [Print] Netherlands
PMID18663256 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Erythropoietin
Topics
  • Diagnosis, Differential
  • Erythropoietin (blood)
  • Female
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • Leiomyoma (blood, diagnosis)
  • Middle Aged
  • Polycythemia (blood, diagnosis)
  • Syndrome
  • Uterine Neoplasms (blood, diagnosis)

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