Thrombospondin-1 in differentiated thyroid cancer: Dr. Jekyll and Mr. Hyde.

Abstract

Thrombospondin-1 (TSP-1) is a member of a family of five structurally related extracellular glycoproteins that plays a major role in cell-matrix and cell-cell interactions. Due to its multifunctional nature and its ability to bind to a variety of cell surface receptors and matrix proteins, TSP-1 has been identified as a potential regulator of angiogenesis and tumor progression. In this review, we summarize recent results that we obtained in our laboratory dealing with the regulation of thombospondin-1 expression by epidermal growth factor and hepatocyte growth factor. Our results show that TSP-1 can have opposite effects on cell invasion depending upon the type of differentiated thyroid carcinoma studied.

• Authors: Christelle Ghoneim, Mahdhia Soula-Rothhut, Bernard Rothhut
• Journal: Connective tissue research (Connect Tissue Res) Vol. 49 Issue 3 Pg. 257-60 ( 2008) ISSN: 1607-8438 [Electronic] England
• PMID: 18661355 (Publication Type: Journal Article, Review)

Chemical References

• Intercellular Signaling Peptides and Proteins
• Thrombospondin 1
• Epidermal Growth Factor
• Hepatocyte Growth Factor

Topics

• Carcinoma, Papillary (metabolism, pathology)
• Carcinoma, Papillary, Follicular (metabolism, pathology)
• Down-Regulation
• Epidermal Growth Factor (metabolism)
• Extracellular Matrix (metabolism)
• Hepatocyte Growth Factor (metabolism)
• Humans
• Intercellular Signaling Peptides and Proteins (metabolism)
• Thrombospondin 1 (metabolism)
• Thyroid Neoplasms (metabolism, pathology)
• Up-Regulation