Neuroendocrine ductal carcinoma in situ (NE-DCIS) of the breast--comparative clinicopathological study of 20 NE-DCIS cases and 274 non-NE-DCIS cases.

Abstract

UNLABELLED:

Kawasaki T, Nakamura S, Sakamoto G, Murata S, Tsunoda-shimizu H, Suzuki K, Takahashi O, Nakazawa T, Kondo T & Katoh R (2008) Histopathology53, 288-298Neuroendocrine ductal carcinoma in situ (NE-DCIS) of the breast - comparative clinicopathological study of 20 NE-DCIS cases and 274 non-NE-DCIS cases Aims: To clarify the clinicopathological significance of breast neuroendocrine ductal carcinoma in situ (NE-DCIS), i.e. DCIS in which >50% of cells immunohistochemically express NE markers (chromogranin A and/or synaptophysin), 20 NE-DCIS were studied and the findings compared with those of 274 non-NE-DCIS.

METHODS AND RESULTS:

NE-DCIS accounted for 6.8% of all DCIS. Mean patient age was 50.4 years for NE-DCIS and 49.6 years for non-NE-DCIS (P = 0.66). The main clinical presentation of NE-DCIS was a bloody nipple discharge, seen in 72%, significantly different from the 5% in non-NE-DCIS cases (P < 0.01). Carcinoma was preoperatively diagnosed in 67% of NE-DCIS and 95% of non-NE-DCIS cases (P < 0.01). NE-DCIS was histologically characterized by a predominantly solid growth of cancer cells with fine-granular cytoplasm and ovoid, or occasionally spindle-shaped nuclei. A well-developed vascular network was also common. Nuclear grades and Van Nuys classification were significantly lower for NE-DCIS than for non-NE-DCIS (P < 0.01). The mean MIB-1 labelling index was 4.3% in NE-DCIS and 8.1% in non-NE-DCIS (P < 0.01). Furthermore, NE-DCIS cases had significantly higher oestrogen and progesterone receptor and lower HER2 scores than non-NE-DCIS cases (P < 0.01).

CONCLUSIONS:

NE-DCIS has characteristic clinicopathological features and can, therefore, be regarded as a distinct variant of DCIS.

• Authors: T Kawasaki, S Nakamura, G Sakamoto, S Murata, H Tsunoda-Shimizu, K Suzuki, O Takahashi, T Nakazawa, T Kondo, R Katoh
• Journal: Histopathology (Histopathology) Vol. 53 Issue 3 Pg. 288-98 (Sep 2008) ISSN: 1365-2559 [Electronic] England
• PMID: 18657193 (Publication Type: Comparative Study, Journal Article)

Topics

• Adult
• Aged
• Breast Neoplasms (pathology)
• Carcinoma in Situ (pathology)
• Carcinoma, Ductal, Breast (pathology)
• Carcinoma, Intraductal, Noninfiltrating (pathology)
• Carcinoma, Neuroendocrine (pathology)
• Female
• Humans
• Immunohistochemistry
• Middle Aged
• Retrospective Studies