Rapid carvedilol up-titration in hospitalized patients with systolic heart failure.

Abstract

To determine whether carvedilol can be safely up-titrated before hospital discharge, we studied 372 consecutive patients with systolic heart failure who were being treated with carvedilol. Carvedilol was initiated a median of 3 days after admission, with a mean starting dose of 12 mg. Up-titration was performed in 67% of patients, with a mean increase of 16 mg and a mean discharge daily dose of 23 +/- 17 mg. Mean daily dose at the end of follow-up was 35.3 +/- 25.3 mg and it increased with higher discharge dose.

• Authors: Manuel Martínez-Sellés, Tomás Datino, Marta Alhama, Nelida Barrueco, Isabel Castillo, Francisco Fernández-Avilés
• Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (J Heart Lung Transplant) Vol. 27 Issue 8 Pg. 914-6 (Aug 2008) ISSN: 1557-3117 [Electronic] United States
• PMID: 18656807 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carbazoles
• Propanolamines
• Vasodilator Agents
• Carvedilol

Topics

• Aged
• Carbazoles (therapeutic use)
• Carvedilol
• Dose-Response Relationship, Drug
• Female
• Heart Failure, Systolic (drug therapy)
• Humans
• Inpatients
• Male
• Middle Aged
• Propanolamines (therapeutic use)
• Retrospective Studies
• Time Factors
• Titrimetry
• Vasodilator Agents (therapeutic use)